Redox Homeostasis Modulators in Cancer Bibliography

Antitumor quinols: role of glutathione in modulating quinol-induced apoptosis and identification of putative cellular protein targets. Chew EH, Matthews CS, Zhang J, McCarroll AJ, Hagen T, Stevens MF, Westwell AD, Bradshaw TD. Biochemical and Biophysical Research Communications, 2006, 346, 242-251.

Novel thioredoxin inhibitors paradoxically increase hypoxia-inducible factor-alpha expression but decrease functional transcriptional activity, DNA binding, and degradation. Jones DT, Pugh CW, Wigfield S, Stevens MF, Harris AL. Clinical Cancer Research, 2006, 12, 5384-5394.

Elucidation of Thioredoxin as a Molecular Target for Antitumor Quinols. Bradshaw TD, Matthews CS, Cookson J, Chew E-H, Shah M, Bailey K, Monks A, Harris E, Westwell AD, Wells G, Laughton CA and Stevens MFG. Cancer Research, 2005, 65, 3911-3919.

Quinols as Novel Therapeutic Agents. 2. 4-(1-Arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and Related Agents as Potent and Selective Antitumor Agents. Berry JM, Bradshaw TD, Fichtner I, Ren R, Schwalbe CH, Wells G, Chew E-H, Stevens MFG and Westwell AD. J. Med. Chem., 2005, 48, 639-644.

Cytotoxic and anti-angiogenic activity of AW464 (NSC 706704), a novel thioredoxin inhibitor: An in vitro study. Mukherjee A, Bradshaw TD, Westwell AD, Stevens MFG, Carmichael J, Martin SG. Brit. J. Cancer, 2005, 92, 350-358.

Chemical and structural studies on thioredoxin-inhibitory antitumour quinols. Westwell AD, McCarroll AJ, Berry JM, Ren R, Rathbone DL, Lowe PR, Schwalbe CH, Burke M, Laughton CA, Stevens MFG. Eur. J. Cancer,2004, 2(8), 40.

Preclinical evaluation of AW464 (NSC 706704), a novel thioredoxin inhibitor. Mukherjee A, Bradshaw TD, Westwell AD, Stevens MFG, Carmichael J, Martin SG. Brit. J. Cancer, 2004, 91 (Suppl. 1), S9.

Identification of thioredoxin as a molecular target of arsenic trioxide as well as of calcitriol and the novel quinol AW 464: paradigms for chemotherapeutic strategies in APL and Multiple Myeloma. Pallis M, Bradshaw TD, Westwell AD, Grundy M, Stevens MFG, Russell NH. Blood, 2003, 102, 597a.

The thioredoxin inhibitor AW464 and the dithiol oxidant diamide induce apoptosis without accumulation of reactive oxygen species. Pallis M, Bradshaw TD, Westwell AD, Grundy M, Stevens MFG, Russell NH Leukemia, 2003, 17, P25.

Induction of Apoptosis without Redox Catastrophe by Thioredoxin-Inhibitory Compounds. Pallis M, Bradshaw TD, Westwell AD, Grundy M, Stevens MFG and Russell NH. Biochem. Pharmacol., 2003, 66, 1695-1705.

4-Substituted-4-Hydroxycyclohexa-2,5-dien-1-ones with Selective Activities Against Colon and Renal Cancer Cell Lines” Wells G, Berry JM, Bradshaw TD, Burger AM, Seaton A, Wang B, Westwell AD and Stevens MFG. J.Med.Chem., 2003, 46, 532-541.

Identification of thioredoxin as a molecular target of arsenic trioxide as well as of calcitriol and the novel quinol AW 464: paradigms for chemotherapeutic strategies in APL and Multiple Myeloma. Pallis M, Bradshaw TD, Westwell AD, Grundy M, Stevens MFG, Russell NH. Blood 2003, 102, 597a.