Redox Homeostasis Modulators

Through a rational design programme, our team has identified key pharmacophores around a chemical class targeting the modulation of redox homeostasis. Experimental data show that these compounds are potent inducers of oxidative stress, perturb the cell cycle, induce apoptosis and inhibit HIF-1a signal transduction and the expression of VEGF. Anti-tumour activity has been demonstrated in xenograft models against a number of common solid tumours, including colon, breast, renal and pancreatic.